total skin electron beam Therapy (TSEBT)

total skin electron beam Therapy (TSEBT)total skin electron beam Therapy (TSEBT)total skin electron beam Therapy (TSEBT)

total skin electron beam Therapy (TSEBT)

total skin electron beam Therapy (TSEBT)total skin electron beam Therapy (TSEBT)total skin electron beam Therapy (TSEBT)

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Informationen zur Ganzhaut-Elektronen-Bestrahlung

Sprache: Deutsch

Untertitel: Englisch

Clinical Trials

s-misr: Soluble-biomarkers for Mycosis fungoides and Sézary

Recruitment Status:  Recruiting ongoing https://drks.de/search/de/trial/DRKS00030375

Trial will be presented in ESTRO 2023 and DEGRO 2023

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RAMSIS Trial

RAdiotherapy in coMbination with Systemic pegylited Interferon (PEG-INFα) therapy for mycosis fungoideS 

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Clinical Trials

Only 2 fractions radiotherapy

Status:  Published March 2023

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EORTC Guidelines

Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group

Khaled Elsayad ∙ Emmanuella Guenova ∙ Chalid Assaf ∙ Jan P. Nicolay ∙ Franz Trautinger∙ Rudolf Stadler ∙ Cora Waldstein ∙ Tom Boterberg∙ Paul Meijnders ∙ Youlia Kirova ∙ Gabor Dobos ∙ Victor Duque-Santana ∙ Elena Riggenbach ∙ Wael Elsheshtawy ∙ Anne Niezink ∙ Evangelia Papadavid ∙ Julia Scarisbrick ∙ Maarten Vermeer ∙ Karen J. Neelis ∙ Martine Bagot ∙ Maxime Battistella ∙ Pietro Quaglino ∙ Robert Knobler ∙ Werner Kempf ∙ Ahmed Maklad ∙ Sebastian Adeberg ∙ Vassilis Kouloulias ∙ Gabriele Simontacchi ∙ Stefanie Corradini ∙ Laila Königa ∙ Hans Theodor Eich ∙ Richard Cowan∙ Dora Correia

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Real-World Pattern-of-Care Analysis of Primary Cutaneous Lymphomas Radiation Therapy Among European

Khaled Elsayad∙ Emmanuella Guenov ∙ Beatrice Fournier ∙ Carolina Fernandes ∙ Enrico Clementel ∙ Evangelia Papadavid ∙ Marie Beylot Barry ∙ Felix Pavlotsky ∙ Chalid Assaf ∙ Pablo L. Ortiz-Romero ∙ Vassilis Kouloulias∙ Adele de Masson ∙ Stephane Dalle∙ Pierre Clavère ∙ Max Schlaak ∙ Nina Booken ∙ Marion Wobser∙ Christina Mitteldorf ∙ Barzilai Aviv ∙ Virgínia Mareco ∙ Fernando Gallardo ∙ Reinhard Dummer ∙ Markus Gross ∙ Felix Ehret ∙ Andrea Lancia ∙ Bartłomiej Tomasik∙ Lorna Hawley ∙ Vincent Rermouchamps ∙ Mona Abdel-Halim Ibrahim ∙ Ahmed Gawish ∙ Mohamed Abouegylah∙ Martin Stuschke∙ Adinda Baten ∙ Hans Theodor Eich ∙ Lena Specht∙ Mario Levis ∙ Stephen Morris ∙ Belinda Campbell ∙ Jan P. Nicolay ∙ Richard Cowan∙ Dora Correia,  on behalf of the EORTC Cutaneous Lymphoma Tumour Group

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Priv. Doz. Dr. med. habil. Khaled Elsayad

Radiation Oncology Consultant

Chairman of  the Dermato-Oncology Working Group in the German Society of Radiation Oncology

International Lymphoma Radiation Oncology Group (ILROG) Council

EORTC Y-ECI/ROSC & Cutaneous Lymphoma Tumor Group (CTLG)

Inhalt der Website

References

1: Elsayad K, Weishaupt C, Moustakis C, Danzer MF, Müller EC, Rolf D, Stranzenbach R, Livingstone E, Booken N, Stadler R, Eich HT.   Ultrahypofractionated Low-Dose Total Skin Electron Beam in Advanced-Stage Mycosis Fungoides and Sézary Syndrome. Int J Radiat Oncol Biol Phys. 2023 Mar 8:S0360-3016(23)00215-8. doi: 10.1016/j.ijrobp.2023.02.052    📷. Online ahead of print. PMID: 36893819    📷 


2: Oymanns M, Daum-Marzian M, Bellm A, Elsayad K, Eich HT, Assaf C.Near complete responses to concurrent brentuximab vedotin and ultra-hypofractionated low-dose total skin electron beam radiation in advanced cutaneous T-cell lymphoma.  Br J Dermatol. 2023 Jan 23;188(1):145-146. doi: 10.1093/bjd/ljac012 [Titel anhand dieser DOI in Citavi-Projekt übernehmen] .


3: S2k-Guidelines - Cutaneous lymphomas (ICD10 C82 - C86): Update 2021. Dippel E, Assaf C, Becker JC, von Bergwelt-Baildon M, Bernreiter S, Cozzio A, Eich HT, Elsayad K, Follmann M, Grabbe S, Hillen U, Klapper W, Klemke CD, Loquai C, Meiss F, Mitteldorf C, Wehkamp U, Nashan D, Nicolay JP, Oschlies I, Schlaak M, Stranzenbach R, Moritz R, Stoll C, Vag T, Weichenthal M, Wobser M, Stadler R. J Dtsch Dermatol Ges. 2022 Apr;20(4):537-554. doi: 10.1111/ddg.14706 


4: Elsayad K, Rolf D, Sunderkötter C, Weishaupt C, Müller EC, Nawar T, Stranzenbach R, Livingstone E, Stadler R, Steinbrink K, Moritz RKC, Eich HT. Low-dose total skin electron beam therapy plus oral bexarotene maintenance therapy for cutaneous T-cell lymphoma. J Dtsch Dermatol Ges. 2022 Mar;20(3):279-285. doi: 10.1111/ddg.14657. Epub 2022 Jan 5. PMID: 34984837.


5: Nawar T, Elsayad K, Müller EC, Rolf D, Moritz RKC, Bormann E, Weishaupt C, Stranzenbach R, Stadler R, Moustakis C, Assaf C, Livingstone E, Sunderkötter C, Steinbrink K, Eich HT. Quality of life in patients with mycosis fungoides and Sézary syndrome undergoing low-dose total skin electron beam therapy with or

without maintenance therapy. J Am Acad Dermatol. 2022 Apr;86(4):889-891. doi: 10.1016/j.jaad.2021.03.025. Epub 2021 Mar 17. PMID: 33722549.


6: Rolf D, Elsayad K, Eich HT. Ultra-hypofractionated low-dose total skin electron beam followed by maintenance therapy: Preliminary findings from a prospective open-label study. J Am Acad Dermatol. 2021 Dec;85(6):1601-1603. doi: 10.1016/j.jaad.2020.11.058. Epub 2020 Nov 30. PMID: 33271220; PMCID: PMC7836520.


7: Rolf D, Elsayad K, Eich HT. Acute and sub-acute toxicity profile of ultra- hypofractionated low-dose total skin electron beam with two 4 Gy fractions for cutaneous T cell lymphoma. J Cancer Res Clin Oncol. 2021 Jun;147(6):1757-1761. doi: 10.1007/s00432-020-03449-7. Epub 2020 Nov 21. PMID: 33219856; PMCID:

PMC7680066.


8: Elsayad K, Stadler R, Steinbrink K, Eich HT. Combined total skin radiotherapy and immune checkpoint inhibitors: A promising potential treatment for mycosis fungoides and Sezary syndrome. J Dtsch Dermatol Ges. 2020 Mar;18(3):193-197. doi: 10.1111/ddg.14044. Epub 2020 Feb 20. PMID: 32077638.


9: Elsayad K, Kroeger K, Greve B, Moustakis C, Assaf C, Stadler R, Lenz G, Weishaupt C, Eich HT. Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome. Strahlenther Onkol. 2020

Jan;196(1):77-84.  nglish. doi: 10.1007/s00066-019-01517-7. Epub 2019 Oct 7.

PMID: 31591658.


1 : Elsayad K, Moustakis C, Simonsen M, Bäcker D, Haverkamp U, Eich HT. In-vivo dosimetric analysis in total skin electron beam therapy. Phys Imaging Radiat Oncol. 2018 May 19;6:61-65. doi: 10.1016/j.phro.2018.05.002. PMID: 33458390;

PMCID: PMC7807580.


11: Kroeger K, Elsayad K, Moustakis C, Haverkamp U, Eich HT. Low-dose total skin electron beam therapy for cutaneous lymphoma : Minimal risk of acute toxicities. Strahlenther Onkol. 2017 Dec;193(12):1024-1030. English. doi: 10.1007/s00066-017-1188-8. Epub 2017 Aug 7. PMID: 28785772.


12: Elsayad K, Susek KH, Eich HT. Total Skin Electron Beam Therapy as Part of Multimodal Treatment Strategies for Primary Cutaneous T-Cell Lymphoma. Oncol Res Treat. 2017;40(5):244-252. doi: 10.1159/000475634 . Epub 2017 Apr 25. PMID: 28448985.


13: Elsayad K, Oertel M, Haverkamp U, Eich HT. The effectiveness of radiotherapy for leukemia cutis. J Cancer Res Clin Oncol. 2017 May;143(5):851-859. doi: 10.1007/s00432-016-2338-6. Epub 2017 Jan 16. PMID: 28093639.


14: Elsayad K, Kriz J, Moustakis C, Scobioala S, Reinartz G, Haverkamp U, Willich N, Weishaupt C, Stadler R, Sunderkötter C, Eich HT. Total Skin Electron Beam for Primary Cutaneous T-cell Lymphoma. Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):1077-86. doi: 10.1016/j.ijrobp.2015.08.041. Epub 2015 Sep 5. PMID:

26581145.

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