total skin electron beam Therapy (TSEBT) page

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Clinical Trials

EORTC Pattern-of-care analysis of primary cutaneous lymphoma

Status:  Published January 2025

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Clinical Trials

Only 2 fractions radiotherapy

Status:  Published March 2023

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Studies for Primary cutaneous lymphoma patients

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S-MISR Register: Soluble-biomarkers for MF, SS, and CBCL

Recruiting ongoing


Principal Investigator: Priv. Doz. Dr. med. habil. Khaled Elsayad


Results have been presented at: 

  • ESTRO 2023 and DEGRO 2023
  • ESTRO 2025 (Abstracts 598 and 1128)
  • JDDG 2025 (original article)
  • JCO Oncology advances 2025 (original article)

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RAMSIS Study: RAdiotherapy in combination with systemic peg-

Recruiting ongoing


Principal Investigator: Priv. Doz. Dr. med. habil. Khaled Elsayad

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EORTC Guidelines

Radiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group

Khaled Elsayad ∙ Emmanuella Guenova ∙ Chalid Assaf ∙ Jan P. Nicolay ∙ Franz Trautinger∙ Rudolf Stadler ∙ Cora Waldstein ∙ Tom Boterberg∙ Paul Meijnders ∙ Youlia Kirova ∙ Gabor Dobos ∙ Victor Duque-Santana ∙ Elena Riggenbach ∙ Wael Elsheshtawy ∙ Anne Niezink ∙ Evangelia Papadavid ∙ Julia Scarisbrick ∙ Maarten Vermeer ∙ Karen J. Neelis ∙ Martine Bagot ∙ Maxime Battistella ∙ Pietro Quaglino ∙ Robert Knobler ∙ Werner Kempf ∙ Ahmed Maklad ∙ Sebastian Adeberg ∙ Vassilis Kouloulias ∙ Gabriele Simontacchi ∙ Stefanie Corradini ∙ Laila Königa ∙ Hans Theodor Eich ∙ Richard Cowan∙ Dora Correia

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Real-World Pattern-of-Care Analysis of Primary Cutaneous Lymphomas Radiation Therapy Among European

Khaled Elsayad∙ Emmanuella Guenov ∙ Beatrice Fournier ∙ Carolina Fernandes ∙ Enrico Clementel ∙ Evangelia Papadavid ∙ Marie Beylot Barry ∙ Felix Pavlotsky ∙ Chalid Assaf ∙ Pablo L. Ortiz-Romero ∙ Vassilis Kouloulias∙ Adele de Masson ∙ Stephane Dalle∙ Pierre Clavère ∙ Max Schlaak ∙ Nina Booken ∙ Marion Wobser∙ Christina Mitteldorf ∙ Barzilai Aviv ∙ Virgínia Mareco ∙ Fernando Gallardo ∙ Reinhard Dummer ∙ Markus Gross ∙ Felix Ehret ∙ Andrea Lancia ∙ Bartłomiej Tomasik∙ Lorna Hawley ∙ Vincent Rermouchamps ∙ Mona Abdel-Halim Ibrahim ∙ Ahmed Gawish ∙ Mohamed Abouegylah∙ Martin Stuschke∙ Adinda Baten ∙ Hans Theodor Eich ∙ Lena Specht∙ Mario Levis ∙ Stephen Morris ∙ Belinda Campbell ∙ Jan P. Nicolay ∙ Richard Cowan∙ Dora Correia,  on behalf of the EORTC Cutaneous Lymphoma Tumour Group

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webinar series

Organised and moderated by Dora Correia, Khaled Elsayad and Gwydion Lyn between November 2024 and February 2025.

Watch the webinars

EORTC webinar series

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Priv. Doz. Dr. med. habil. Khaled Elsayad

Radiation Oncology Consultant, Germany

Chairman of  the Dermato-Oncology Working Group in the German Society of Radiation Oncology

International Lymphoma Radiation Oncology Group (ILROG) Council

EORTC Y-ECI/ROSC & Cutaneous Lymphoma Tumor Group (CTLG)

References

  1.  Elsayad K, Kandler C, Siats JJ, Pepper N, Danzer MF, Dobos G, Livingstone E, Melchers S, Kleemann J, Hyun J, Pföhler C, von den Driesch P, Nicolay JP, Stadler R, Eich HT. Low-dose total skin electron beam therapy in erythrodermic mycosis fungoides and Sézary syndrome: Results From the Prospective S-MISR Study. J Dtsch Dermatol Ges. 2025 Aug 23. doi: 10.1111/ddg.15851. Epub ahead of print. PMID: 40847689.
  2. Khaled Elsayad, Isabel Falke, Rudolf Stadler, Yenny Angela, David Rene Steike, Christos Moustakis, Judith Reuther, Carsten Weishaupt, Moritz Fabian Danzer, Claudia Pföhler, Martin Gschnell, Lisa Krönig, Johannes Kleemann, Bastian Schilling, Nicole Kreuzberg, Gabor Dobos, Christina Mitteldorf, Friederike Hoffmann, Jennifer Landsberg, Peter von den Driesch, Elisabeth Livingstone, Chalid Assaf, Edgar Dippel, Burkhard Greve, Hans Theodor Eich. Low-Dose Total Skin Electron Beam Radiotherapy in Stage IB-IIB Mycosis Fungoides: Results From the Prospective S-MISR Study. JCO Oncology Advances 2025 :2. DOI:10.1200/OA-25-00065
  3. Elsayad K, Stadler R, Eich HT. Pegylated Interferon Combined With Low-Dose Total Skin Electron Beam Therapy for Advanced Stage Mycosis Fungoides: Two Case Reports and Literature Review. Adv Radiat Oncol. 2024 Oct 28;10(1):101663. doi: 10.1016/j.adro.2024.101663. PMID: 39619150; PMCID: PMC11605184. 
  4.  Heger A, Elsayad K, Kandler C, Siats J, Oertel M, Kittel C, Eich HT. Health-related quality of life in primary cutaneous B-cell lymphoma following local radiotherapy. JAAD Int. 2024 Jul 30;17:53-54. doi: 10.1016/j.jdin.2024.07.002. PMID: 39411237; PMCID: PMC11474179. 
  5. Elsayad,  Kandler, Siats,  Pepper, Danzer, Dobos, Livingstone, Melchers, Kleemann,  Hyun,  Pföhler, von den Driesch,  Nicolay, Stadler,  Eich, (Abstract A-167) Durable disease control with low-dose total skin electron beam therapy combined with maintenance treatment for patients with erythrodermic mycosis fungoides and Sézary syndrome,European Journal of Cancer,Volume 211, Supplement 2,2024, 114477,ISSN 0959-8049, https://doi.org/10.1016/j.ejca.2024.114477 
  6. Elsayad K, Weishaupt C, Moustakis C, Danzer MF, Müller EC, Rolf D, Stranzenbach R, Livingstone E, Booken N, Stadler R, Eich HT.   Ultrahypofractionated Low-Dose Total Skin Electron Beam in Advanced-Stage Mycosis Fungoides and Sézary Syndrome. Int J Radiat Oncol Biol Phys. 2023 Mar 8:S0360-3016(23)00215-8. doi: 10.1016/j.ijrobp.2023.02.052 . Online ahead of print. PMID: 36893819    
  7. Oymanns M, Daum-Marzian M, Bellm A, Elsayad K, Eich HT, Assaf C.Near complete responses to concurrent brentuximab vedotin and ultra-hypofractionated low-dose total skin electron beam radiation in advanced cutaneous T-cell lymphoma.  Br J Dermatol. 2023 Jan 23;188(1):145-146. doi: 10.1093/bjd/ljac012 [Titel anhand dieser DOI in Citavi-Projekt übernehmen] .
  8. S2k-Guidelines - Cutaneous lymphomas (ICD10 C82 - C86): Update 2021. Dippel E, Assaf C, Becker JC, von Bergwelt-Baildon M, Bernreiter S, Cozzio A, Eich HT, Elsayad K, Follmann M, Grabbe S, Hillen U, Klapper W, Klemke CD, Loquai C, Meiss F, Mitteldorf C, Wehkamp U, Nashan D, Nicolay JP, Oschlies I, Schlaak M, Stranzenbach R, Moritz R, Stoll C, Vag T, Weichenthal M, Wobser M, Stadler R. J Dtsch Dermatol Ges. 2022 Apr;20(4):537-554. doi: 10.1111/ddg.14706 
  9. Elsayad K, Rolf D, Sunderkötter C, Weishaupt C, Müller EC, Nawar T, Stranzenbach R, Livingstone E, Stadler R, Steinbrink K, Moritz RKC, Eich HT. Low-dose total skin electron beam therapy plus oral bexarotene maintenance therapy for cutaneous T-cell lymphoma. J Dtsch Dermatol Ges. 2022 Mar;20(3):279-285. doi: 10.1111/ddg.14657. Epub 2022 Jan 5. PMID: 34984837.
  10. Nawar T, Elsayad K, Müller EC, Rolf D, Moritz RKC, Bormann E, Weishaupt C, Stranzenbach R, Stadler R, Moustakis C, Assaf C, Livingstone E, Sunderkötter C, Steinbrink K, Eich HT. Quality of life in patients with mycosis fungoides and Sézary syndrome undergoing low-dose total skin electron beam therapy with or
  11. without maintenance therapy. J Am Acad Dermatol. 2022 Apr;86(4):889-891. doi: 10.1016/j.jaad.2021.03.025. Epub 2021 Mar 17. PMID: 33722549.
  12. Rolf D, Elsayad K, Eich HT. Ultra-hypofractionated low-dose total skin electron beam followed by maintenance therapy: Preliminary findings from a prospective open-label study. J Am Acad Dermatol. 2021 Dec;85(6):1601-1603. doi: 10.1016/j.jaad.2020.11.058. Epub 2020 Nov 30. PMID: 33271220; PMCID: PMC7836520.
  13. Rolf D, Elsayad K, Eich HT. Acute and sub-acute toxicity profile of ultra- hypofractionated low-dose total skin electron beam with two 4 Gy fractions for cutaneous T cell lymphoma. J Cancer Res Clin Oncol. 2021 Jun;147(6):1757-1761. doi: 10.1007/s00432-020-03449-7. Epub 2020 Nov 21. PMID: 33219856; PMCID:PMC7680066.
  14. Elsayad K, Stadler R, Steinbrink K, Eich HT. Combined total skin radiotherapy and immune checkpoint inhibitors: A promising potential treatment for mycosis fungoides and Sezary syndrome. J Dtsch Dermatol Ges. 2020 Mar;18(3):193-197. doi: 10.1111/ddg.14044. Epub 2020 Feb 20. PMID: 32077638.
  15. Elsayad K, Kroeger K, Greve B, Moustakis C, Assaf C, Stadler R, Lenz G, Weishaupt C, Eich HT. Low-dose total skin electron beam therapy: Quality of life improvement and clinical impact of maintenance and adjuvant treatment in patients with mycosis fungoides or Sezary syndrome. Strahlenther Onkol. 2020. Jan;196(1):77-84.  nglish. doi: 10.1007/s00066-019-01517-7. Epub 2019 Oct 7. PMID: 31591658.
  16. Elsayad K, Moustakis C, Simonsen M, Bäcker D, Haverkamp U, Eich HT. In-vivo dosimetric analysis in total skin electron beam therapy. Phys Imaging Radiat Oncol. 2018 May 19;6:61-65. doi: 10.1016/j.phro.2018.05.002. PMID: 33458390;PMCID: PMC7807580.
  17. Kroeger K, Elsayad K, Moustakis C, Haverkamp U, Eich HT. Low-dose total skin electron beam therapy for cutaneous lymphoma : Minimal risk of acute toxicities. Strahlenther Onkol. 2017 Dec;193(12):1024-1030. English. doi: 10.1007/s00066-017-1188-8. Epub 2017 Aug 7. PMID: 28785772.
  18. Elsayad K, Susek KH, Eich HT. Total Skin Electron Beam Therapy as Part of Multimodal Treatment Strategies for Primary Cutaneous T-Cell Lymphoma. Oncol Res Treat. 2017;40(5):244-252. doi: 10.1159/000475634 . Epub 2017 Apr 25. PMID: 28448985.
  19. Elsayad K, Oertel M, Haverkamp U, Eich HT. The effectiveness of radiotherapy for leukemia cutis. J Cancer Res Clin Oncol. 2017 May;143(5):851-859. doi: 10.1007/s00432-016-2338-6. Epub 2017 Jan 16. PMID: 28093639.
  20. Elsayad K, Kriz J, Moustakis C, Scobioala S, Reinartz G, Haverkamp U, Willich N, Weishaupt C, Stadler R, Sunderkötter C, Eich HT. Total Skin Electron Beam for Primary Cutaneous T-cell Lymphoma. Int J Radiat Oncol Biol Phys. 2015 Dec 1;93(5):1077-86. doi: 10.1016/j.ijrobp.2015.08.041. Epub 2015 Sep 5. PMID:26581145.


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